Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice.
Nat Commun. 2020 Jun 15;11(1):3018
Kai Y, Andricovich J, Zeng Z, Zhu J, Tzatsos A*, Peng W*. Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features.
Nat Commun. 2018 Oct 11;9(1):4221 *corresponding authors
Andricovich J, Perkail S, Kai Y, Casasanta N, Peng W, Tzatsos A. Loss of KDM6A activates super-enhancers to induce gender-specific squamous-like pancreatic cancer and confers sensitivity to BET inhibitors.
Cancer Cell. 2018 Mar 12;33(3):512-526
Andricovich J, Kai Y, Tzatsos A. Lysine-specific histone demethylases in normal and malignant hematopoiesis.
Exp Hematol. 2016 Sep;44(9):778-82 (invited review)
Andricovich J, Kai Y, Peng W, Foudi A, Tzatsos A. Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.
J Clin Invest. 2016 Mar 1;126(3):905-20.
Tzatsos A*, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, and Bardeesy N*. KDM2B controls tumorigenesis in pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.
J Clin Invest. 2013 Feb 1;123(2):727-39. *corresponding authors
Tzatsos A*, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N*. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.
J Biol Chem. 2011 Sep 23;286(38):33061-9. *corresponding authors
Tzatsos A. Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.
J Biol Chem. 2009 Aug 21;284(34):22525-34.
Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2641-6.
Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12.
Tzatsos A, Tsichlis PN. Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.
J Biol Chem. 2007 Jun 22;282(25):18069-82.
Tzatsos A*, Kandror KV*. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
Mol Cell Biol. 2006 Jan;26(1):63-76. *corresponding authors
Full list of publications can be found in PubMed
Nat Commun. 2020 Jun 15;11(1):3018
Kai Y, Andricovich J, Zeng Z, Zhu J, Tzatsos A*, Peng W*. Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features.
Nat Commun. 2018 Oct 11;9(1):4221 *corresponding authors
Andricovich J, Perkail S, Kai Y, Casasanta N, Peng W, Tzatsos A. Loss of KDM6A activates super-enhancers to induce gender-specific squamous-like pancreatic cancer and confers sensitivity to BET inhibitors.
Cancer Cell. 2018 Mar 12;33(3):512-526
Andricovich J, Kai Y, Tzatsos A. Lysine-specific histone demethylases in normal and malignant hematopoiesis.
Exp Hematol. 2016 Sep;44(9):778-82 (invited review)
Andricovich J, Kai Y, Peng W, Foudi A, Tzatsos A. Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis.
J Clin Invest. 2016 Mar 1;126(3):905-20.
Tzatsos A*, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, and Bardeesy N*. KDM2B controls tumorigenesis in pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.
J Clin Invest. 2013 Feb 1;123(2):727-39. *corresponding authors
Tzatsos A*, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N*. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.
J Biol Chem. 2011 Sep 23;286(38):33061-9. *corresponding authors
Tzatsos A. Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.
J Biol Chem. 2009 Aug 21;284(34):22525-34.
Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2641-6.
Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE, Tsichlis PN. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process.
Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1907-12.
Tzatsos A, Tsichlis PN. Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.
J Biol Chem. 2007 Jun 22;282(25):18069-82.
Tzatsos A*, Kandror KV*. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
Mol Cell Biol. 2006 Jan;26(1):63-76. *corresponding authors
Full list of publications can be found in PubMed