Dynamics of chromatin architecture during cell transformation. We use Chromatin Interaction Analysis by Paired End Tag Sequencing (ChIA-PET) to map changes in higher order chromatin structure that facilitate cell transformation.
Topological properties of chromatin organization. We employ machine learning and principles of network topology to study 3D chromatin organization by leveraging one dimensional genetic and epigenomic features.
Kai Y, Andricovich J, Zeng Z, Zhu J, Tzatsos A*, Peng W*. Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features. Nat Commun. 2018 Oct 11;9(1):4221 *corresponding authors
ἀγεωμέτρητος μηδεὶς εἰσίτω let no one ignorant of geometry enter Plato's Academy (Athens, Greece, ca. 387 BC)