Dynamics of chromatin architecture during cell transformation. We use Chromatin Interaction Analysis by Paired End Tag Sequencing (ChIA-PET) to map the changes in higher order chromatin structure that facilitate cell transformation. We seek to uncover genetic and epigenetic changes that contribute to oncogenesis by altering long range chromatin interactions.

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Topological properties of chromatin organization. We apply principles of network topology to study chromatin organization and employ machine learning to predict 3D chromatin structure by leveraging one dimensional genetic and epigenomic features.

​Kai Y, Andricovich J, Zeng Z, Zhu J, Tzatsos A*, Peng W*. Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features. Nat Commun. 2018 Oct 11;9(1):4221 *corresponding authors

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ἀγεωμέτρητος μηδεὶς εἰσίτω 
let no one ignorant of geometry enter
Plato's Academy (Athens, Greece, ca. 387 BC)

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