Dynamics of chromatin architecture during cell transformation. We use Chromatin Interaction Analysis by Paired End Tag Sequencing (ChIA-PET) to map the changes in higher order chromatin structure that facilitate cell transformation. We seek to uncover genetic and epigenetic changes that contribute to oncogenesis by altering long range chromatin interactions.
Kai Y, Andricovich J, Zeng Z, Zhu J, Tzatsos A*, Peng W*. Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features. Nat Commun. 2018 Oct 11;9(1):4221 *corresponding authors